Omicron spike protein was less efficiently cleaved compared with Delta. However, in lung cells and gut cells, Omicron demonstrated lower replication.
Replication was similar for Omicron and Delta virus isolates in human nasal epithelial cultures. Importantly, the antiviral drugs remdesivir and molnupiravir retain efficacy against Omicron BA.1. mRNA vaccination as a third vaccine dose rescues and broadens neutralization. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses. The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its spike protein 2. Nature volume 603, pages 706–714 ( 2022) Cite this article The Genotype to Phenotype Japan (G2P-Japan) Consortium,.The CITIID-NIHR BioResource COVID-19 Collaboration,.
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
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